Basic physical and chemical properties: convex pills of yellow color with greenish or orange hue; with engraving “spa” on the one hand.
Means used in functional gastrointestinal disorders. Code ATX A0ZA D02.
Drotaverin is a derivative of isoquinoline, which exhibits antispasmodic effect directly on smooth muscle by inhibiting the action of the enzyme phosphodiesterase IV (FDE IV), which causes an increase in the concentration of cAMP and, due to the inactivation of the lung chains of myosin kinase (MLCK), leads to relaxation of smooth muscle.
In vitro, drotaverin inhibits the action of the enzyme PDE IV and does not affect the effect of isoenzymes of phosphodiesterase III (PDE III) and phosphodiesterase V (PDE V). PDE IV has a great functional significance for reducing the contractile activity of smooth muscle, so particular inhibitors of this enzyme may be beneficial for the treatment of diseases that are accompanied by hypertrophy, as well as various diseases in which there are gastrointestinal cramps.
In the cells of the smooth muscle of the myocardium and vessels, cAMP is hydrolyzed mostly by the isoenzymes of PDE III, so drotaverin is an effective antispasmodic remedy that has no notable side effects from the cardiovascular system and has a strong therapeutic effect on this system.
Drotaverin is effective at spasms of smooth muscle as a nervous and muscular origin. Drotaverin acts on the smooth muscle of the gastrointestinal, biliary, genitourinary and vascular systems, regardless of the type of their autonomous innervation.
It enhances blood circulation in tissues due to its ability to expand vessels.
The action of drotaverine is stronger than that of papaverine; absorption is faster and more complete, it is less associated with serum proteins. The advantage of drotaverin is also that, unlike papaverine, after its parenteral administration, there is no such side effect as breathing stimulation.
Spasms of smooth muscle associated with diseases of the biliary tract: cholecystolithiasis, cholangioolithiasis, cholecystitis, perihelocystitis, cholangitis, papillitis.
Spasms of smooth muscle in infections of the urinary tract: nephrolithiasis, ureterolithiasis, pyelitis, cystitis, tonsils of the bladder.
As an auxiliary treatment:
- with spasms of the smooth muscle of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, gastritis, cardiopulmonary and pylorospasm, enteritis, colitis, spastic colitis with constipation and irritable bowel syndrome accompanied by flatulence;
- headache tension;
- with gynecological diseases: dysmenorrhea.
Symptoms: severe cardiac arrhythmias and conduction abnormalities have been observed with a significant overdose of drotaverin, including complete blockage of the Gisson bundle and cardiac arrest that can be fatal.
In case of overdose, the patient should be carefully monitored by the doctor and receive symptomatic treatment, including vomiting and rinsing the stomach.
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Adverse reactions observed during clinical trials and may have been caused by drotaverine, distributed by system organ and frequency of occurrence: very common (> 1/10), standard (> 1/100, <1/10), uncommon (> 1/1000, <1/100), single (> 1/10000, <1/1000), very rare (<1 / 10,000), frequency unknown: cannot be estimated from the available data.
On the part of the immune system. Alone: allergic reactions, including angioneurotic edema, urticaria, rash, itching, skin hyperemia, fever, chills, fever, weakness.
From the cardiovascular system. Single: rapid heartbeat, arterial hypotension.
From the nervous system. Lonely: a headache, dizziness, insomnia.
From the gastrointestinal tract. Lonely: nausea, constipation, vomiting.
Keep out of the reach of children.
Store in original packaging at temperatures below + 25 ° C.